Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts.

摘要: Staphylococcus aureus is a bacterial pathogen causing approximately 80% of all cases human osteomyelitis. This bacterium can adhere to and become internalized by osteoblasts previous studies indicate that are active in the internalization process. In current study, we examined roles microfilaments, microtubules clathrin-dependent receptor-mediated endocytosis S. MC3T3-E1 mouse osteoblast cells. Microfilament microtubule polymerization was inhibited with cytochalasin D colchicine. Clathrin-coated pit formation using transaminase inhibitor, monodanslycadaverine. The results this study utilize actin clathrin-coated pits aureus; however, microfilaments seem play most significant role invasion