Development and evaluation of novel itraconazole-loaded intravenous nanoparticles.

摘要: Abstract The purpose of this study was to present novel intravenous itraconazole-loaded nanoparticles (ITZ-NPs) using human serum albumin (HSA) as drug carrier materials. ITZ-NPs were prepared by nanoparticle bound technology involving a series homogenization and lyophilization procedures. powder could be easily reconstituted provide stable solutions at wide range concentrations 25 °C for 24 h. In safety test, the caused mild hemolysis below concentration 10 mg/mL well tolerated dose 160 mg/kg in mice, indicating better biocompatibility than cyclodextrin formulation itraconazole (ITZ-CD). pharmacokinetic parameters its major metabolite, hydroxyl-itraconazole, had no differences from those ITZ-CD mice. For group, distributions lung, liver spleen higher group. It significance that increased distribution lung which always portal fungal infection. These results indicate can potential itraconazole.