Limited survival of adult human testicular tissue as ectopic xenograft

摘要: Background Grafting of testicular tissue into immunodeficient mice has become an interesting and promising scientific tool for the generation gametes study function. This technique might potentially be used to generate sperm from patients whose testes need removed or are destroyed due therapeutic intervention as a consequence disease. Here we explore whether adult human with different pathologies survives xenograft. Methods results Testis varying degrees spermatogenesis was grafted two strains (severe combined immunodeficiency, Nu/Nu). Tissue active prior grafting largely regressed. However, survival better in cases where suppressed occasionally spermatogonial stem cells survived. Cases spermatogenic disruption were not corrected by xenografting. Conclusion Superior germinal epithelium spermatogonia when could provide novel strategy germline preservation pre-pubertal cancer patients. approach also valuable early stages spermatogenesis.