Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1

摘要: The recent outbreak of enterovirus 71 (EV71) infected millions children and caused over 1,000 deaths. To date, neither an effective vaccine nor antiviral treatment is available for EV71 infection. Interferons (IFNs) have been successfully applied to treat patients with hepatitis B C viral infections decades but failed infections. Here, we provide the evidence that antagonizes type I IFN signaling by reducing level interferon receptor 1 (IFNAR1). We show host cells could sense infection stimulate IFN-β production. However, induction downstream IFN-stimulated genes inhibited EV71. Also, only a slight response effects be detected in treated recombinant IFNs after Further studies reveal blocks IFN-mediated phosphorylation STAT1, STAT2, Jak1, Tyk2 IFNAR1. Finally, identified 2A protease encoded as antagonist activity required IFNAR1 levels. Taken together, our study first time uncovers mechanism used antagonize provides new targets future strategies.