Syndecans as Cell Surface Receptors in Cancer Biology. A Focus on their Interaction with PDZ Domain Proteins.

摘要: Syndecans are transmembrane receptors with ectodomains that modified by glycosaminoglycan chains. The can interact a wide variety of molecules, including growth factors, cytokines, proteinases, adhesion receptors, and extracellular matrix components. four syndecans in mammals expressed development-, cell-type-, tissue-specific manner function either as co-receptors other cell surface or independent mediate signaling. They help regulate proliferation migration, angiogenesis, cell/cell cell/extracellular adhesion, they may participate several key tumorigenesis processes. In some cancers, syndecan expression regulates tumor proliferation, motility, functions, be prognostic marker for progression patient survival. short cytoplasmic tail is likely to involved these events through recruitment signaling partners. particular, the conserved carboxyl-terminal EFYA tetrapeptide sequence present all binds PDZ domain-containing proteins scaffold recruit cytoskeletal plasma membrane. There growing interest understanding interactions at both structural biological levels, recent findings show their high degree complexity. Parameters influence domain syndecans, such binding specificity affinity, focus active investigations important regulatory mechanisms. Recent studies affected post-translational mechanisms, phosphorylation within tail.