Phosphine-Mediated Dimerization of Conjugated Ene-Yne Ketones: Stereoselective Construction of Dihydrobenzofurans
作者： Cheng-Zhi Zhu , Yao-Liang Sun , Yin Wei , Min Shi
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摘要: A new strategy for the phosphine-mediated dimerization of conjugated ene-yne ketones to produce functionalized dihydrobenzofurans has been developed, affording diversified 4,5-dihydrobenzofurans in moderate excellent yields with high diastereoselectivities under mild conditions. This synthetic method can tolerate a variety functional groups and be performed on gram scale an asymmetric variant using chiral phosphine Xyl-BINAP give desired products up 94% ee.
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