Kallikrein-kinin system in chronic subdural haematomas : its roles in vascular permeability and regulation of fibrinolysis and coagulation

摘要: The kallikrein-kinin system is closely related to both fibrinolysis and coagulation, bradykinin--the end product of this system--is a powerful mediator which increases vascular permeability. In the present study, test hypothesis that plays part in aetiology chronic subdural haematomas, components (prekallikrein, high molecular weight kininogen (HMW-kininogen), bradykinin), those fibrinolytic coagulation systems were measured at 134 haematoma sites 119 patients. activities prekallikrein HMW-kininogen haematomas significantly lower than plasma patients, showed parallel decrease. bradykinin concentration was higher plasma. These results indicate activation haematomas. also shown, there significant correlation between plasminogen, fibrin/fibrinogen degradation products, or platelets This suggests regulation by mutual stimulation these systems. outer membrane, perivascular haemorrhage, interstitial oedema, leucocyte migration evident microscopically, indicating an increase protein peripheral blood, exudation from capillaries membrane. system, increasing permeability, may cause blood extravasation into membrane cavity, resulting enlargement haematoma.