Meta-analysis of the association between preoperative anaemia and mortality after surgery.

摘要: BACKGROUND Numerous published studies have explored associations between anaemia and adverse outcomes after surgery. However, there are no evidence syntheses describing the impact of preoperative on postoperative outcomes. METHODS A systematic review meta-analysis observational exploring was performed. Studies investigating trauma, burns, transplant, paediatric obstetric populations were excluded. The primary outcome 30-day or in-hospital mortality. Secondary acute kidney injury, stroke myocardial infarction. Predefined analyses performed for cardiac non-cardiac surgery subgroups. post hoc analysis undertaken to evaluate relationship infection. Data presented as odds ratios (ORs) with 95 per cent c.i. RESULTS From 8973 records, 24 eligible including 949 445 patients identified. Some 371 594 (39·1 cent) anaemic. Anaemia associated increased mortality (OR 2·90, 2·30 3·68; I(2)  = 97 cent; P < 0·001), injury 3·75, 2·95 4·76;  = 60 P < 0·001) infection 1·93, 1·17 3·18;  = 99 P = 0·01). Among surgical patients, 1·28, 1·06 1·55;  = 0 P = 0·009) but not infarction 1·11, 0·68 1·82;  = 13 P = 0·67). an incidence red cell transfusion 5·04, 4·12 6·17;  = 96 P < 0·001). Similar findings observed in CONCLUSION Preoperative is poor surgery, although heterogeneity significant. It remains unclear whether independent risk factor simply a marker underlying chronic disease. much more frequent amongst anaemic patients.