Immune response to inactivated influenza virus vaccine: antibody reactivity with epidemic influenza B viruses of two highly distinct evolutionary lineages

摘要: Vaccination of adults (healthy female employees potentially capable transmitting influenza to high-risk persons; n = 104) in autumn 1990 with a trivalent virus vaccine containing B/Yamagata/16/88 induced low antibody response B/Finland/150/90, recent variant B/Victoria/2/87-like viruses, as compared the B/Finland/172/91, current lineage B/Yamagata/16/88-like viruses. Up end epidemic season, status declined but was still significantly better than before vaccination. The results suggest that strain appropriate for outbreak 1991 Finland, may provide unsatisfactory protection against Evidence is given use Madin-Darby canine kidney (MDCK)-grown an antigen haemagglutination inhibition test (HI) more reliable information about protective antibodies untreated or ether-treated egg-grown Significantly higher postvaccination and postepidemic titres were recorded among subjects who exhibited vaccination seronegative subjects. A rate initially people seropositive no clear evidence obtained pre-existing could have had negative effect on production.