Combined Diffusion-Weighted, Blood Oxygen Level–Dependent, and Dynamic Contrast-Enhanced MRI for Characterization and Differentiation of Renal Cell Carcinoma

摘要: Purpose To investigate a multiparametric magnetic resonance imaging (MRI) approach comprising diffusion-weighted (DWI), blood oxygen–dependent (BOLD), and dynamic contrast-enhanced (DCE) MRI for characterization differentiation of primary renal cell carcinoma (RCC). Material Methods Fourteen patients with clear-cell four papillary RCC were examined DWI, BOLD MRI, DCE at 1.5T. The apparent diffusion coefficient (ADC) was calculated monoexponential decay. spin-dephasing rate R2* derived from parametric maps. DCE-MRI analyzed using two-compartment exchange model allowing separation perfusion (plasma flow [FP] plasma volume [VP]), permeability (permeability surface area product [PS]), extravascular extracellular (VE). Statistical analysis performed Wilcoxon signed-rank test, Pearson's correlation coefficient, receiver operating characteristic curve analysis. Results Clear-cell showed higher ADC lower compared to subtypes, but differences not significant. FP subtypes significantly than in RCC. Perfusion parameters moderate significant inverse R2*. VE ADC. Fp Vp best sensitivity histological differentiation. Conclusion Multiparametric BOLD, is feasible assessment moderately correlates MRI–derived perfusion. shows the volume, does correlate tumor oxygenation or In this preliminary study appeared superior DWI