Unlocking the Complexities of Tumor-Associated Regulatory T Cells.

摘要: Regulatory T (Treg) cells are found at elevated densities in many human cancers and thought to be a major barrier the generation of robust antitumor cell responses. In this review, we discuss recent advances understanding tumor-associated Treg diversity function. Emerging evidence indicates that transcriptional program infiltrating may represent composite blending tissue-associated expression signature with an additional tumor-specific common from multiple cancer types. Studies mouse models have defined unique molecular pathways required for function tumor context can manipulated selectively dampen intratumoral activity. Finally, expanding body work has revealed diverse functions nonlymphoid tissues unrelated immune suppression, suggesting need explore beyond regulation immunity.