MicroRNA Profiling and Its Application in Drug Discovery in Pancreatic Cancer

摘要: MicroRNAs (miRNAs) are single-stranded small RNA molecules of 21–23 nucleotides in length, involved regulation gene expression. An emerging number studies show that miRNAs play a vital role important signaling pathways human oncogenesis. can be utilized as potential biomarkers for cancer diagnosis and also candidates treatment drug development. Pancreatic is lethal disease the fourth leading cause cancer-related deaths United States. One key factor make an impact earlier disease, when surgery could offer patients chance cure. Use early detection development offers unique opportunity. Identification assessment miRNA functionality differentially expressed pancreatic originates from methods profiling such microarray, situ hybridization, various computational algorithms applied data analysis. This chapter discusses to identification cancer, which towards cancer.