Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application.

摘要: Tixocortol pivalate is a corticosteroid with topical anti-inflammatory activity equal to that of hydrocortisone. It was evaluated in group 18 normal subjects determine whether it exerted any systemic glucocorticoid after single oral or intrarectal doses and short-term dosing by the intranasal route. Effects tixocortol were compared those dexamethasone betamethasone 21-phosphate. By three routes, does not induce changes plasma Cortisol, leukocyte counts (neutrophils, lymphocytes, monocytes, eosinophils), blood glucose, 24-hr urinary excretion sodium potassium, whereas there betamethasone. pivalate, however, increased free cortisol-like substances. concluded given for short periods nonparenteral routes measurable effect. Clinical Pharmacology Therapeutics (1983) 33, 343–350; doi:10.1038/clpt.1983.43