Assessment of Vasoactive Agents and Vascular Aging by the Second Derivative of Photoplethysmogram Waveform

摘要: Abstract —To evaluate the clinical application of second derivative fingertip photoplethysmogram waveform, we performed drug administration studies (study 1) and epidemiological 2). In study 1, ascending aortic pressure was recorded simultaneously with its in 39 patients a mean±SD age 54±11 years. The augmentation index defined as ratio height late systolic peak to that early pulse. consists an a, b, c, d wave systole e diastole. Ascending increased after injection 2.5 μg angiotensin from 126/74 160/91 mm Hg decreased 0.3 mg sublingual nitroglycerin 111/73 Hg. d/a, wave, −0.40±0.13 −0.62±0.19 −0.25±0.12 ( P r =0.79, =0.80, y ) x =0.023 −1.515). aging higher 126 subjects any history diabetes mellitus, hypertension, hypercholesterolemia, ischemic heart disease than age-matched without such (−0.06±0.36 versus −0.22±0.41,