Transgenic Approaches to Study the Functions of the Transforming Growth Factor-β Superfamily Members
作者： Anthony L. Lau , Weinian Shou , Qiuxia Guo , Martin M. Matzuk
DOI: 10.1007/978-1-4612-1874-6_22
关键词:
摘要: The tranforming growth factor-β (TGF-β)-related proteins belong to a large superfamily of secreted factors (1). New members the family are still being discovered through homology-based techniques, and more than 25 mammalian have been (1–9). in vivo functions many these new currently not known. Embryonic stem (ES) cell technology (10–12), powerful genetic tool, has allowed delineation essential function some thus opened up avenues research by uncovering unknown functions. With increasing use ES technology, mutant mouse strains generated analyzed which TGF-β family, their receptors, or ligand-binding rendered functionally inactive. This chapter focuses on those genes that recently “knocked out” (Table 22.1). As signaling pathways for studied greater detail, importance this reproduction, development, oncogenesis will become increasingly clear.
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