Development, evaluation and effect of anionic co-ligand on the biological activity of benzothiazole derived copper(II) complexes.

摘要: Abstract Research on development of novel metal based anti-cancer agents continues with its popularity among bioinorganic community. Benzothiazole, an important heterocyclic pharmacophore, was chosen as a valuable and useful scaffold for the synthesis copper(II) complexes. Three new complexes obtained from newly synthesized benzothiazole N-(benzo[d]thiazol-2-ylmethyl)-N-methyl-2-(pyridin-2-yl)ethan-1-amine (btzpy) ligand CuCl2 [Cu(btzpy)Cl2] (1), Cu(NCS)2 [Cu(btzpy)(NCS)2] (2), Cu(NO3)2 [Cu(btzpy)(NO3)(H2O)]NO3 (3) were isolated characterized by physical spectroscopic measurements, including single-crystal X-ray structures. The interaction 1 3 calf thymus (CT)-DNA investigated using ethidium bromide fluorescence quenching assay weak intercalation KSV values 9.8 × 102 M−1 8.2 × 102 M−1, respectively observed. All three have shown DNA cleavage supercoiled plasmid forming single nicked double forms in presence external reducing like 3-mercaptopropionic acid (3-MPA) ascorbic acid. water-soluble also show prominent hydrolytic cleavage. From DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, it observed that complex 2 exhibits good antioxidant properties. cytotoxicity 1–3 tested against lung cancer cell line (A549) -NCS moiety shows maximum activity micromolar range. A rationale is proposed light other properties these molecules.