BRCA1 is a histone-H2A-specific ubiquitin ligase.
作者： Reinhard Kalb , Donna L. Mallery , Conor Larkin , Jeffrey T.J. Huang , Kevin Hiom
DOI: 10.1016/J.CELREP.2014.07.025
关键词:
摘要: … (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA … of the BRCA1/BARD1 ubiquitin ligase remain unclear. Here, we show that BRCA1/BARD1 …
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Angus Chen, Frida E. Kleiman, James L. Manley, Toru Ouchi, Zhen-Qiang Pan, Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. Journal of Biological Chemistry. ,vol. 277, pp. 22085- 22092 ,(2002) , 10.1074/JBC.M201252200
Matthew L Bentley, Jacob E Corn, Ken C Dong, Qui Phung, Tommy K Cheung, Andrea G Cochran, Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. The EMBO Journal. ,vol. 30, pp. 3285- 3297 ,(2011) , 10.1038/EMBOJ.2011.243
Peter S. Brzovic, Ponni Rajagopal, David W. Hoyt, Mary-Claire King, Rachel E. Klevit, Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nature Structural & Molecular Biology. ,vol. 8, pp. 833- 837 ,(2001) , 10.1038/NSB1001-833
Van A.T. Huynh, Philip J.J. Robinson, Daniela Rhodes, A Method for the In Vitro Reconstitution of a Defined “30 nm” Chromatin Fibre Containing Stoichiometric Amounts of the Linker Histone Journal of Molecular Biology. ,vol. 345, pp. 957- 968 ,(2005) , 10.1016/J.JMB.2004.10.075
Karolin Luger, Structure and dynamic behavior of nucleosomes. Current Opinion in Genetics & Development. ,vol. 13, pp. 127- 135 ,(2003) , 10.1016/S0959-437X(03)00026-1
H. Ruffner, C. A. P. Joazeiro, D. Hemmati, T. Hunter, I. M. Verma, Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 5134- 5139 ,(2001) , 10.1073/PNAS.081068398
P.T Lowary, J Widom, New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning. Journal of Molecular Biology. ,vol. 276, pp. 19- 42 ,(1998) , 10.1006/JMBI.1997.1494
Sarah Elderkin, Goedele N. Maertens, Mitsuhiro Endoh, Donna L. Mallery, Nick Morrice, Haruhiko Koseki, Gordon Peters, Neil Brockdorff, Kevin Hiom, A Phosphorylated Form of Mel-18 Targets the Ring1B Histone H2A Ubiquitin Ligase to Chromatin Molecular Cell. ,vol. 28, pp. 107- 120 ,(2007) , 10.1016/J.MOLCEL.2007.08.009
R. Shakya, L. J. Reid, C. R. Reczek, F. Cole, D. Egli, C.-S. Lin, D. G. deRooij, S. Hirsch, K. Ravi, J. B. Hicks, M. Szabolcs, M. Jasin, R. Baer, T. Ludwig, BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity Science. ,vol. 334, pp. 525- 528 ,(2011) , 10.1126/SCIENCE.1209909
Donna L Mallery, Cassandra J Vandenberg, Kevin Hiom, Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains The EMBO Journal. ,vol. 21, pp. 6755- 6762 ,(2002) , 10.1093/EMBOJ/CDF691