Decreased phenytoin levels in antineoplastic therapy.

摘要: Summary: A case history is reported illustrating the difficulties which may be encountered in maintaining seizure control patients being treated with antineoplastic therapy. The maintenance of therapeutic serum levels phenytoin during combined cis-platinum and bleomycin sulfate therapy suggests an absorptive defect, possibly related to damage intestinal mucosa. This defect did not appear alter absorption primidone or phenobarbital, since increased dosages were necessary maintain these drugs within ranges.