Hormone replacement therapy and sleep-disordered breathing.

摘要: Disordered breathing during sleep is more common among postmenopausal women than their premenopausal counterparts, possibly because of declining levels estrogen and progesterone. We examined the relationship between use replacement hormones sleep-disordered in a sample 2,852 noninstitutionalized women, 50 years age or older, who participated Sleep Heart Health Study. The frequency apneas hypopneas per hour (apnea–hypopnea index) was determined by unattended, single-night polysomnography at participant's home. prevalence index 15 more) hormone users (61 907) approximately half nonusers (286 1,945). Multivariable adjustment for known determinants disorder, including age, body mass index, neck circumference, has attenuated association, but only moderately (adjusted odds ratio, 0.55; 95% confidence interval, 0.41 to 0.75). inverse associ...