Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b5 and Cytochrome P450 Reductase
作者： John B. Schenkman
DOI: 10.1007/978-1-4684-7284-4_11
关键词:
摘要: While cytochrome P450 has only been known for a relatively short time (1), and its role in xenobiotic metabolism an even shorter period (2), b5 much longer (see review, 3). Both of these hemoproteins are present the endoplasmic reticulum number tissue, particularly liver. Only last two decades found to play liver microsomal monooxygenations (4–6). The original report involvement (7) was attempt explain NADH synergism NADPH-supported drug oxidations (8). Subsequent studies including those discussed this lecture, have resulted implication monooxygenations, but do not earlier reported NADH-synergism.
springer.com
springerlink.com参考文章(32)
Philipp Strittmatter, Harry A. Dailey, Essential Structural Features and Orientation of Cytochrome b5 in Membranes Springer, Boston, MA. pp. 71- 82 ,(1982) , 10.1007/978-1-4684-4082-9_9
John B. Schenkman, David Kupfer, Hepatic cytochrome P-450 monooxygenase system Pergamon Press. ,(1982)
P P Tamburini, R E White, J B Schenkman, Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5. Journal of Biological Chemistry. ,vol. 260, pp. 4007- 4015 ,(1985) , 10.1016/S0021-9258(18)89223-7
A Loverde, P Strittmatter, The role of lysyl residues in the structure and reactivity of cytochrome B5 reductase. Journal of Biological Chemistry. ,vol. 243, pp. 5779- 5787 ,(1968) , 10.1016/S0021-9258(18)91932-0
Tsuneo Omura, Ryo Sato, A New Cytochrome in Liver Microsomes Journal of Biological Chemistry. ,vol. 237, pp. 1375- ,(1962) , 10.1016/S0021-9258(18)60338-2
D A Carrino, A I Caplan, Isolation and characterization of proteoglycans synthesized in ovo by embryonic chick cartilage and new bone Journal of Biological Chemistry. ,vol. 260, pp. 122- 127 ,(1985) , 10.1016/S0021-9258(18)89702-2
E. C. Miller, R. R. Brown, J. A. Miller, A. H. Conney, The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system. Cancer Research. ,vol. 17, pp. 628- 633 ,(1957)
W L Backes, C E Reker-Backes, The effect of NADPH concentration on the reduction of cytochrome P-450 LM2. Journal of Biological Chemistry. ,vol. 263, pp. 247- 253 ,(1988) , 10.1016/S0021-9258(19)57385-9
Philippe L. Gigon, James R. Gillette, Theodore E. Gram, Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates. Molecular Pharmacology. ,vol. 5, pp. 109- 122 ,(1969)
T. D. Porter, C. B. Kasper, Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 973- 977 ,(1985) , 10.1073/PNAS.82.4.973