Maternal separation alters drug intake patterns in adulthood in rats.
作者： M.C. Moffett , A. Vicentic , Marie Kozel , Paul Plotsky , D.D. Francis
DOI: 10.1016/J.BCP.2006.08.003
关键词:
摘要: Maternal separation/handling (MS/H) is an animal model of early life stress that causes profound neurochemical and behavioral alterations in pups persist into adulthood. Many recent studies have used the MS/H to study changes drug effects adulthood are linked treatments stressors perinatal period. The focused on this review reinforcing properties abused drugs, cocaine alcohol. A striking finding variations maternal separation handling cause ethanol self-administration. Further, these indicate various manipulations period can long lasting interest biochemical pharmacologists. This article will self-administration using may play a role Studying provide important clues vulnerability abuse perhaps identify crucial window opportunity for therapeutic intervention.
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