A Research Agenda for Helminth Diseases of Humans: Basic Research and Enabling Technologies to Support Control and Elimination of Helminthiases
作者： Sara Lustigman , Peter Geldhof , Warwick N Grant , Mike Y Osei-Atweneboana , Banchob Sripa
DOI: 10.1371/JOURNAL.PNTD.0001445
关键词:
摘要: Successful and sustainable intervention against human helminthiases depends on optimal utilisation of available control measures development new tools strategies, as well an understanding the evolutionary implications prolonged parasite populations those their hosts vectors. This will depend largely updated knowledge relevant fundamental biology. There is a need, therefore, to exploit apply techniques in order make significant novel gains combating supporting sustainability current successful mass drug administration (MDA) programmes. Among fields basic research that are likely yield improved tools, Disease Reference Group Helminth Infections (DRG4) has identified four broad areas stand out central next generation helminth measures: 1) genetics, genomics, functional genomics; 2) immunology; 3) (vertebrate) host-parasite interactions immunopathology; 4) (invertebrate) transmission The DRG4 was established 2009 by Special Programme for Research Training Tropical Diseases (TDR). given mandate undertake comprehensive review recent advances identify notable gaps highlight priority areas. paper summarises discusses challenges investigation biology parasites under Group's remit according priorities, presents agenda enabling technologies help support elimination efforts helminthiases.
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