Immune response to traumatic injury: harmony and discordance of immune system homeostasis.

摘要: Trauma remains one of the leading causes death worldwide. Traumatic injury disrupts immune system homeostasis and may predispose patients to opportunistic infections inflammatory complications. Prevention multiple organ dysfunction syndrome due septic complications following severe trauma is a challenging problem. Following injury, usually tends toward pro-inflammatory phenotype then changes counter-inflammatory phenotype. This believed be protective response based on balance between innate adaptive systems. We reported that activates inflammasomes primes Toll-like receptors. The primed prepared for rapid strong antimicrobial defense. However, can also develop "two-hit" augments regulatory T cell activity, which control in trauma. discuss current idea traumatic induces unique type triggered by damage-associated molecular pattern molecules, are combination endogenous danger signal molecules include alarmins pathogen-associated molecules.