FDG-PET Contributions to the Pathophysiology of Memory Impairment
作者： Shailendra Segobin , Renaud La Joie , Ludivine Ritz , Hélène Beaunieux , Béatrice Desgranges
DOI: 10.1007/S11065-015-9297-6
关键词:
摘要: Measurement of synaptic activity by Positron Emission Tomography (PET) and its relation to cognitive functions such as episodic memory, working memory executive in healthy humans patients with neurocognitive disorders have been well documented. In this review, we introduce the concept PET imaging that allows observation a particular biological process vivo through use radio-labelled compounds, general medical world contributions understanding systems. We then focus on [18F]-2-fluoro-2-deoxy-D-glucose (FDG-PET), radiotracer is used measure local cerebral metabolic rate glucose indicative brain. FDG-PET at rest has forefront functional neuroimaging over past 3 decades, contributing how these patterns change alterations. discuss methodological considerations are important for optimizing data prior analysis. highlight contribution differences non-degenerative pathologies, normal ageing, age-related neurodegenerative disorders. Through reasonable temporal spatial resolution, ability whole brain, independently any specific network disease, makes it ideal observe regional changes associated impairment.
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