Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys.
作者： Atsuo Tomidokoro , Makoto Araie , Yasuhiro Tamaki , Miyuki Nagahara , Mikio Fujii
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摘要: PURPOSE To investigate the effects of topical nipradilol on blood velocity in optic nerve head (ONH) normal humans and ocular periocular distribution topically instilled monkeys. METHODS In humans, 0.25% was one eye vehicle other twice daily for 7 days, ONH measured by laser speckle method. monkeys, after a single instillation 1% [(14)C]nipradilol eye, radioactivity evaluated whole-head autoradiography. RESULTS Twice-daily 7-day temporarily but significantly increased human velocity, ipsilateral only (P = 0.005), independent reduction intraocular pressure. equivalent concentration tissue around insertion higher side than contralateral (140 +/- 25 ng/g 42 10 ng/g, P 0.022, n 5). Radioactivity behind equator 0.004), not side. The posterior retina-choroid 636 92 which that control (521 < 0.001). CONCLUSIONS increase induced attributed to drug penetrated locally. Whole-head autoradiographic study suggests can rapidly reach at pharmacologic concentrations.
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