Alternative Palladium‐Catalyzed Vinylic C−H Difluoroalkylation of Ketene Dithioacetals Using Bromodifluoroacetate Derivatives
作者： Shuangquan Tian , Xiaoning Song , Dongsheng Zhu , Mang Wang
关键词:
摘要: A palladium-catalyzed cross-coupling of α-oxo ketene dithioacetals and bromodifluoroacetate derivatives has been developed for the synthesis a class CF2-containing tetra-substituted olefins, which potential to extend drug design material application. The process is proposed involve two single electron transfer processes accompanied by an alternative loop from palladium(0) palladium(I), likely due unique structural properties with β,β-dialkylthiol substituents on olefin double bond.
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