Applications of genes coding antibacterial peptides and genes fusing proteins in preparation of medicines for treating helicobacter pylori diseases

作者: Wang Jianfei , Jiang Anmin , Gong Chengliang , Zhang Qinyuan , Fan Tao

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摘要: The invention provides applications of genes coding antibacterial peptides and fusing proteins in preparation medicines for treating helicobacter pylori diseases belongs to the field pharmacy. amino acid sequence is shown as SEQ ID NO:1. fusion protein has following primary structure: carrier protein-connecting peptide-antibacterial peptide, wherein peptide an resistance, high stability activity a stomach environment can serve active ingredient be used preparing diseases, using process drug tolerance difficultly caused.

参考文章(2)
Loren D. Walensky, Rida Mourtada, Gregory H. Bird, Stabilized anti-microbial peptides ,(2016)
Xiaolin Zhang, Anmin Jiang, Guisheng Wang, Hao Yu, Banghua Qi, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang, Fusion expression of the PGLa-AM1 with native structure and evaluation of its anti- Helicobacter pylori activity Applied Microbiology and Biotechnology. ,vol. 101, pp. 5667- 5675 ,(2017) , 10.1007/S00253-017-8302-9