Pharmacology—Lithium Absorption, Distribution, Renal Handling, and Effect on Body Electrolytes

摘要: Lithium is rapidly absorbed by the gastrointestinal tract. Blood levels peak after single oral doses of lithium between 2 to 4 hours (Amdisen, 1969; Platman et al., 1968; Trautner 1955). Accordingly, in clinical practice blood are measured at least 8 last dose avoid sampling during these peaks. This very rapid absorption has led introduction slow-release forms achieve more constant Coppen and Bailey, 1970). It possible that avoiding extreme flings permitting precise monitoring serum concentration, incidence lithium-induced side effects will eventually be reduced.