SH3 and SH2: Prototypic Domains to Mediate Regulatory Mechanisms in the Cell

摘要: Protein organization and function can be looked at as originating from a combination of small subset domains each carrying an independent modular function. Although many domain families exist that mediate protein interaction, for historical reasons the characterization SRC homology SH2 SH3 has laid foundation new way thinking about cell yielded framework discovery analysis much larger family interaction domains. bind proteins phospho-tyrosines therefore offer mechanism to sense changes caused by signals modulate phosphorylation tyrosines.