Sodium Transport Mechanisms in the Mammalian Nephron

摘要: Na transport is highly coordinated and regulated along the length of renal nephron. The proximal tubule reabsorbs majority filtered Na. transcellular, through action Na-antiporters Na-coupled cotransporters. responsible for reabsorption by In thick ascending limb Henle, cotransported with other ions. This nephron segment critical urine concentration. distal collecting duct make smallest contribution to reabsorption. However, in these segments subject stringent regulation external balance under normal physiological conditions. basic structure function transporters are evaluated. Hormonal signaling pathways that regulate also discussed.