Evidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury.
作者： Edyta Paczkowska , Dorota Rogińska , Ewa Pius-Sadowska , Alina Jurewicz , Katarzyna Piecyk
DOI: 10.1179/2045772314Y.0000000227
关键词:
摘要: Context/objective Traumatic spinal cord injury (SCI) leads to disruption of local vasculature inducing secondary damage neural tissue. Circulating endothelial progenitor cells (EPCs) play an important role in post-injury regeneration vasculature, whereas (ECs) reflect damage. Methods Twenty patients with SCI were assessed during the first 24 hours, at day 3, and 7 compared 25 healthy subjects. We herein investigated EPC EC counts by flow cytometry as well levels soluble factors (SDF-1, HGF, VEGF, Ang2, EGF, endoglin, PLGF, FGF-2, ET-1, BDNF, IGF-1) regulating their migration proangiogenic function. To better characterize peripheral blood (PB) cells, global gene expression profiles PB-derived determined using genome-wide RNA microarray technology. Results found significantly higher (CD34+/CD133+/VEGFR2+) (VEGFR2+) count PB within days increased E...
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