The Pathogenic Role of Antineutrophil Cytoplasmic Autoantibodies

摘要: Antineutrophil cytoplasmic autoantibodies (ANCA) are found in the sera of patients with systemic necrotizing vasculitis and glomerulonephritis. Their role pathogenesis these diseases is not clearly understood; however, there a growing body data that supports pathogenic function for antibodies. In vitro they can activate neutrophils monocytes to produce reactive oxygen species (ROS), degranulate, damage target cells. The antigens which directed stimulate T lymphocytes from diseases. ANCA against proteinase 3 (PR3) may also play growth regulation by inactivating enzymatic its antigen. proposed model ANCA-induced disease takes into account both natural history