Morphological changes in the thalamus and neocortex of the cat brain after a restricted unilateral fetal neocortical lesion

摘要: In order to study the response of brain injury during early development, neocortex ten fetal kittens was lesioned at age E43-48, in either frontal (n = 8) or parieto-occipital 2) areas. The thalamus and animals were analyzed using quantitative morphometry compared intact control cats 10). Ipsilaterally, volumes remaining 26.5% 25.7% smaller, respectively (P < 0.05). Contralaterally, did not change volume, whereas tended be smaller by a mean 11.1%. all four thalamic nuclei studied, neuronal glial cell packing densities (NCPD GCPD) cross sectional area somata differ between except for principal ventromedial nucleus, where GCPD significantly lower 0.05) animals. NCPD show any differences groups, which Furthermore, contralateral basal than 0.01). These results indicate loss neurons glia ipsilateral probably neocortex. Since, time cortical resection, transient reciprocal thalamosubplate connections have been established cat, lesion-induced deprivation subplate target inputs precluded survival substantial number developing neurons. cortex hypothetical may, least partly, attributed elimination before establishment corticocortical connections.