2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors.
作者： Ravindra K. Rawal , Yenamandra S. Prabhakar , S.B. Katti , E. De Clercq
DOI: 10.1016/J.BMC.2005.07.063
关键词:
摘要: A series of 4-thiazolidinones were evaluated as selective inhibitors the HIV-RT enzyme. Our attempt in correlating derived physicochemical properties with inhibitory activity resulted some statistically significant QSAR models good predictive ability. The studies indicated role lipophilicity, dipole moment and out-of-plane potential energy compounds rationalizing activity. One compounds, 1, inhibited enzyme at 0.204 μM concentration minimal toxicity to MT-4 cells.
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