Effect of insulin and contraction up on glucose transport in skeletal muscle

摘要: The major glucose transporter protein expressed in skeletal muscle is GLUT4. Both contraction and insulin induce translocation of GLUT4 from the intracellular pool to plasma membrane. pathways that lead contraction- insulin-stimulated seem be different, allowing attainment a maximal effect when acting together. Insulin utilizes phosphatidylinositol 3-kinase-dependent mechanism, whereas exercise signal may initiated by calcium release sarcoplasmic reticulum or autocrine- paracrine-mediated activation transport. During more than at rest. However, endurance training leads decreased utilization during sub-maximal exercise, spite large increase total content associated with training. mechanisms involved this reduction have not been totally elucidated, but appear cause decrease amount translocated membrane altering exercise-induced enhancement transport capacity. On other hand, resistance controversial. Recent studies, however, demonstrated improvement sensitivity correlated increasing mass. New studies should designed define molecular basis for these important adaptations muscle. Since utilize insulin-independent uptake, provide knowledge understanding managing peripheral resistance.