Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses

摘要: Background: Mucosal Associated Invariant T (MAIT) cells are innate-like found in abundance the intestinal mucosa, and thought to play a role bridging innate-adaptive interface. Methods: We measured MAIT cell frequencies antibody responses blood from patients presenting with cultureconfirmed severe cholera hospital Dhaka, Bangladesh at days 2, 7, 30, 90 of illness. Results: that (CD3 + CD4 2 CD161 hi Va7.2 ) were maximally activated day 7 after onset cholera. In adult patients, did not change over time, whereas child MAITs significantly decreased this decrease persisted 90. Fold changes frequency correlated increases LPS IgA IgG, but IgM nor toxin B subunit. Conclusions: acute phase cholera, activated, depleted periphery, as part innate response against V. cholerae infection, possibly involved mechanisms underlying class switching cell-independent antigens.