ORIGINAL RESEARCH—ENDOCRINOLOGY: Hypogonadism, Decreased Sexual Desire, and Long-Term Depression in Middle-Aged Men

摘要: ABSTRACT Introduction In middle-aged men, the associations between long-term depressive symptoms and circulating testosterone levels are poorly known, although it is known that decrease with age. Methods A health questionnaire was mailed to a population-based sample from National Population Register in 1998, 1999, 2001. Based on their self-reported mental symptoms, total of 116 men were selected for clinical examination 2005. Half them had high others low adverse all three previous follow-ups. structured interview Diagnostic Statistical Manual Mental Disorders-IV performed. Depressive assessed Beck Depression Inventory (BDI) Hamilton Rating Scale (HDRS). The Aging Males’ Symptoms scale also compiled determined. Results entire study sample, serum free correlated negatively both BDI HDRS scores. hypogonadism group (based testosterone, 19.8% sample), clinically significant depression (BDI score ≥ 13) more than times as frequent other (34.8% vs. 10.4%), odds ratio after multiple adjustments being 4.98 (95% confidence interval 1.66–14.95). sexual desire common (36%). Nevertheless, associated depression, irrespective levels. Discussion Long-term current decreased desire, men. Hypogonadism per se cause may be contributory possibly treatable factor underlying male depression. Conclusions findings highlight need hormonal status assessment Hintikka J, Niskanen L, Koivumaa-Honkanen H, Tolmunen T, Honkalampi K, Lehto SM, Viinamaki H. Hypogonadism, J Sex Med 2009;6:2049–2057.