Part I. DNA flow cytometry as a prognostic indicator in head and neck cancer

摘要: The prognostic significance of deoxyribonucleic acid (DNA) flow cytometry has been investigated for many solid tumors, but few data have accumulated squamous cell carcinomas the head and neck. To our knowledge, we report largest number patients (69) with neck primary to be studied by DNA cytometry. In first part this study, reviewed 109 consecutive laryngeal or hypopharyngeal which were treated at North Carolina Memorial Hospital during period 1981 1984. final analysis comprised 139 histograms (mean coefficient variation: 8.02) on paraffin-embedded specimens from 48 patients. Of carcinomas, 24 had glottic, 18 supraglottic, 6 piriform sinus. Patients follow-up a minimum 12 months, mean 23 months. Twenty-three (48%) clearly aneuploid, remaining 52% tetraploi...