Ultrasound-triggered perfluorocarbon-derived nanobombs for targeted therapies of rheumatoid arthritis
作者： Bihui Zhu , Liyun Wang , Jianbo Huang , Xi Xiang , Yuanjiao Tang
DOI: 10.1039/C9TB00978G
关键词:
摘要: Several kinds of therapeutic agents and methods are emerging to meet the increasing demand for a more effective rheumatoid arthritis (RA) therapy. However, developing an ultrasound (US)-responsive nanosystem treatment RA is still filled with challenges. Herein, US-triggered perfluorocarbon (PFC)-based “nanobombs” reported targeted RA. The nanobombs were synthesized by thin-film hydration sonication method had core perfluoropentane (PFP)-based nanodroplets (NDs) loaded glucocorticoid dexamethasone (Dex) shell folic acid (FA)-grafted polyethylene glycol (PEG)-functionalized phospholipid (PFP-Dex@NDs-PEG-FA). 1 MHz US used as initiator could trigger “explosion” enhance drug release. high concentration PFP-Dex@NDs-PEG-FA showed highest cytotoxicity on activated RAW264.7 cells, which main cells in lesions, while cellular uptake tests conducted demonstrated that modified FA increase cells. Moreover, combined exhibited excellent inhibition synovitis joint destruction collagen-induced SD rat model, acting efficient agent Therefore, this study, PFC-based treat would offer new strategy thus have great potential application areas theranostic nanomedicine treatment.
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