Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction.
作者： Junkai Fu , Yueqing Gu , Hao Yuan , Tuoping Luo , Song Liu
DOI: 10.1038/NCOMMS9617
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摘要: The development of an efficient diastereoselective synthesis the oxabicyclo[3.2.1]octane ring system bearing two oxygenated quaternary chiral centres represents a significant challenge. This motif can be found in wide range natural products with biological activities. Here we report such kind scaffold using cyclohexane-trans-1,4-diol alkyne side chain presence Au(I) catalyst. is domino process which C–H, C–O and one C–C bond assembled through sequence cyclization/semi-pinacol rearrangements. strategy has been successfully applied to asymmetric formal total (+)-cortistatins.
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