Metaplastic and mitotic activity of the ischemic (endocrine) kidney in experimental renal hypertension.

摘要: Partial ligation of the aorta between renal arteries in rat induces malignant hypertension, metaplasia smooth-muscle cells arterioles and into juxtaglomerular cells, a complex series events tubular at all levels ischemic kidney. The outer cortex, particularly proximal convoluted show very rapid progressive simple atrophy. In contrast, necrosis individual is followed by mitotic activity atrophic inner medulla, papilla. Subsequently, polyploidy hyperplasia occur cortex. At same time, hypertrophy protein-synthesizing apparatus an increase protein, DNA, RNA, decrease protein content, are seen medulla papilla, proceeds side with waves activity. These take place, albeit to lesser degree, even cases mild ischemia. While they may unrelated these changes probably involved hydrolytic enzyme characteristic