Therapeutic effect of curcumin and C60 fullerene against hyperglycemia-mediated tissue damage in diabetic rat lungs
作者： Ersin Demir
DOI: 10.1007/S10863-020-09861-5
关键词:
摘要: Increasing evidence suggests that diabetes also targets lung tissues resulting in structural and physiological abnormalities. The present study evaluated the impact of pristine C60 fullerene (C60) against diabetes-induced damage for first time. objective was to evaluate impacts Curcumin (Cur), fullerene+Curcumin (C60 + Cur) combination on oxidative stress (MDA, GSH, CAT, GST, Retinol, α-tocopherol), apoptosis (Caspase-3, Bcl-2), cholesterol fatty acid profile (16:0,18:0,18:1,18:2, 22:4, 22:6) changes tissue diabetic rats. Streptozotocin (STZ) used inducing with Cur, C60 + Cur administered eight weeks treat control Increased stress, significant cell structure were observed reduced rats while increasing antioxidant defense capacity tissue, exhibiting protective properties apoptosis. displayed favorable lipotoxicity-induced due increase levels tissue. It displays effects hyperglycemia induced Oxidative prevention lipid accumulation, weakening may be associated these effects.
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