Molecular Biology of Vascular Remodeling

摘要: The earliest form of vascular remodeling occurs during embryonic development, formation. In this process endothelial cells arise and a dense plexus throughout the mesoderm. This then remodels to recognizable branching pattern. has been considered be primarily an cell event. It is now increasingly clear that actually represents complex coordinated development involving smooth muscle cells. Recent gene-targeting experiments have begun dissect signaling pathways mediate various aspects process, which appears regulated by secreted factors physical forces. Subsequently, there extensive as primitive pattern reorganizes reflect definitive circulation found in higher vertebrates. And finally, continuous embryogenesis postnatal organism increases size.