Non-steroidal glucocorticoid inhibitors and their use in treating inflammation, allergy and auto-immune conditions

作者: James Michael Woolven , Simon John Fawcett Macdonald , Haydn Terence Jones , Philip Alan Skone , Ian Baxter Campbell

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摘要: The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the and preparation said compositions, intermediates use manufacture medicament therapeutic treatment, particularly treatment inflammation, allergy and/or auto-immune conditions.

参考文章(5)
Derek Anthony Demaine, Maria Victoria Vinader, Stephen Shanahan, Michael John Johnston, Simon John Fawcett Macdonald, David House, Haydn Terence Jones, Philip Alan Skone, Michael David Barker, Iain Mcfarlane Mclay, Graham George Adam Inglis, Non-steroidal infalmmation inhibitors ,(2004)
Younes Bekkali, Rajashekhar Betageri, Hossein Razavi, Pingrong Liu, Ji Wang, Thomas Wai-Ho Lee, David S. Thomson, Hidenori Takahashi, Michael J. Emmanuel, Doris Riether, Usha R. Patel, John Robert Proudfoot, Christian H.J.J. Harcken, Thomas Martin Kirrane, Daniel Kuzmich, Renee Zindell, Abdelhakim Hammach, 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo ,(2004)
Raj Betageri, Yan Zhang, Renee M. Zindell, Daniel Kuzmich, Thomas M. Kirrane, Jörg Bentzien, Mario Cardozo, Alison J. Capolino, Tazmeen N. Fadra, Richard M. Nelson, Zofia Paw, Daw-Tsun Shih, Cheng-Kon Shih, Ljiljana Zuvela-Jelaska, Gerald Nabozny, David S. Thomson, Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 4761- 4769 ,(2005) , 10.1016/J.BMCL.2005.07.025
Diane Mary Coe, James Michael Woolven, Simon John Fawcett Macdonald, Haydn Terence Jones, Philip Alan Skone, Steven Philip Keeling, Ian Baxter Campbell, Heather Anne Barnett, Gordon Gad Weingarten, Iain Mcfarlane Mclay, Graham George Adam Inglis, Anthony William James Cooper, Phenyl-pyrazole derivatives as non-steroidal glucocoricoid receptor ligands ,(2007)