Unsuspected plasticity of single neurons after connection of the corticospinal tract with peripheral nerves in spinal cord lesions.

摘要: Objective : To report an unsuspected adaptive plasticity of single upper motor neurons and primary cortex found after microsurgical connection the spinal cord with peripheral nerve via grafts in paraplegics focussed discussion reviewed literature. Methods The research aimed at making walk again, 20 years experimental surgery animals. Amongst other things, animal experiments demonstrated alteration endplates receptors from cholinergic to glutamatergic induced by neurons. same paradigm was successfully performed paraplegic humans. were put into ventral-lateral tract randomly, without possibility choosing axons coming different areas cortex. Results patient became able selectively activate re-innervated muscles she wanted concurrent activities connected cortical areas. Conclusion Authors believe that unlike or tendon transfers, where whole area corresponding transfer changes its function a phenomenon we call “brain areas”, our due direct nerves learning occurs based on neuronal so simultaneous contractions are prevented. We propose it functional “plasticity neurons”. speculate this is activation spread for given specific movement, whilst not activated time. Why fire times according voluntary demands remains be discovered. committed solve enigma hereafter.