Expression patterns of the Wtx/Amer gene family during mouse embryonic development
作者： Glenda Comai , Agnes Boutet , Yasmine Neirijnck , Andreas Schedl
DOI: 10.1002/DVDY.22313
关键词:
摘要: WTX/AMER1 is a novel negative regulator of the WNT/β-catenin pathway with mutations detected in Wilms' tumors and an X-linked sclerosing bone dysplasia. (Fam123b) shares several domains homology two other recently identified proteins: AMER2 (Fam123a) AMER3 (Fam123c). Here, we describe in-depth expression analysis all three members this gene family during mouse embryonic development. All genes were strongly expressed central as well peripheral nervous system, thus suggesting important roles neurogenesis. Specific was found retina, inner ear, nasal epithelium. Outside system Wtx/Amer1 showed broadest including cephalic limb mesenchyme, skeletal muscle, bladder, gonads, lung bud, salivary glands, kidneys. The widespread pattern Wtx/Amer1, together its role modulator Wnt signaling pathway, suggest that serves pleiotropic mammalian organogenesis. Developmental Dynamics 239:1867–1878, 2010. © 2010 Wiley-Liss, Inc.
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