Gene immunotherapy for non-small cell lung cancer.

作者: John J. J. Nemunaitis

DOI: 10.1007/978-1-59745-561-9_26

关键词:

摘要: Historically, limited results have been observed with immunity in non-small cell lung cancer (NSCLC). In the last 5 years, however, several immune-stimulating products demonstrated enhancement of tumor antigen recognition through activation dendritic cell-involved processes. Moreover, clinical benefit has subsets patients, justifying ongoing phase III investigation. Results key gene immunotherapies being tested NSCLC are reviewed. Preliminary advanced suggest evidence well-tolerated immune suggested respect to survival and response.

参考文章(105)
Bruce W. S. Robinson, David R. Fitzpatrick, Bernadette Scott, Amanda L. Marzo, Antisense Oligonucleotides Specific for Transforming Growth Factor β2 Inhibit the Growth of Malignant Mesothelioma Both in Vitro and in Vivo Cancer Research. ,vol. 57, pp. 3200- 3207 ,(1997)
Eckhard R. Podack, Thomas R. Malek, James P. Allison, Bai Liu, Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors. Journal of Immunology. ,vol. 156, pp. 1117- 1125 ,(1996)
K Strommer, C Siepl, I Heid, A Fontana, S Bodmer, N de Tribolet, K Frei, Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2. Journal of Immunology. ,vol. 143, pp. 3222- 3229 ,(1989)
Omid Akbari, Rosemarie H. DeKruyff, Dale T. Umetsu, Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen Nature Immunology. ,vol. 2, pp. 725- 731 ,(2001) , 10.1038/90667
A S Fauci, H C Lane, L M Wakefield, A B Roberts, M B Sporn, J H Kehrl, A H Rook, D B Burlington, Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. Journal of Immunology. ,vol. 136, pp. 3916- 3920 ,(1986)
S L Topalian, S A Rosenberg, D Solomon, Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. Journal of Immunology. ,vol. 142, pp. 3714- 3725 ,(1989)
U V Malipiero, A Fontana, M Schachner, D B Constam, J Philipp, P ten Dijke, Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia. Journal of Immunology. ,vol. 148, pp. 1404- 1410 ,(1992)
Chris Coppin, Franz Porzsolt, Michael Autenrieth, Julia Kumpf, Andrew Coldman, Timothy Wilt, Immunotherapy for advanced renal cell cancer Cochrane Database of Systematic Reviews. ,vol. 2015, ,(2015) , 10.1002/14651858.CD001425.PUB2
A Fontana, S Bodmer, E Hofer, R M Zinkernagel, M H Schreier, M A Palladino, K Frei, Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice. Journal of Immunology. ,vol. 143, pp. 3230- 3234 ,(1989)