Greater fibroblast proliferation on an ultrasonicated ZnO/PVC nanocomposite material.

摘要: There has been a significant and growing concern over nosocomial medical device infections. Previous studies have demonstrated that embedding nanoparticles alone (specifically, zinc oxide [ZnO]) in conventional polymers (eg, polyvinyl chloride [PVC]) can decrease bacteria growth may the potential to prevent or disrupt bacterial processes lead infection. However, little no conducted determine mammalian cell functions on such nanocomposite material. Clearly, for certain applications, maintaining healthy while decreasing is imperative (yet uncommon). For this reason, presented study, ZnO of varying sizes (from 10 nm >200 diameter) functionalization (including doping with aluminum functionalizing silane coupling agent KH550) were incorporated into PVC either without ultrasonication. Results study provided first evidence greater fibroblast density after 18 hours culture smallest nanoparticle samples dispersion aided by Specifically, greatest amount proliferation was measured functionalized KH550; sample exhibited nanoparticles. Water droplet tests showed general trend decreased hydrophilicity when adding any PVC, but an increase (albeit still below controls pure PVC) using ultrasonication dispersion. Future will correlate change wettability initial protein adsorption events explain behavior. Mechanical also ability tailor mechanical properties ZnO/PVC nanocomposites through use different Coupled previous antibacterial studies, present highly dispersed materials should be further studied numerous applications.