Allele and genotype frequencies of the two single nucleotide polymorphisms in the VKORC1 gene that are most important for warfarin treatment among Emiratis

摘要: Warfarin is the most widely prescribed anticoagulant worldwide. However, warfarin doses vary up to 20-fold and side-effects (at high doses) or therapy failure lower are major risks of treatment. The target enzyme warfarin, vitamin K epoxide reductase complex 1 (VKORC1), encoded by highly polymorphic VKORC1 gene polymorphisms contributes approximately 30% variability in dose. In this study, we used polymerase chain reaction (PCR) direct DNA sequencing genotype two clinically important variants (rs9923231 rs7294) among Emiratis. We genotyped 117 healthy Emirati nationals found that frequencies rs9923231 genotypes GG, GA AA 0.256, 0.496 0.248, respectively. frequency G allele for single nucleotide polymorphism (SNP) 0.504 while A 0.496. rs7294 0.462, 0.393 0.145, alleles SNP were 0.660 0.340 allele. Genotypes studied SNPs be different between population Indian Chinese populations; however, they similar Caucasians other regional populations, such as Saudis, Turkish Iranians. These findings potentially determining starting dose patients requiring