Association of Cytokine Gene Polymorphisms with Oral Lichen Planus in Malayalam-Speaking Ethnicity from South India (Kerala)
作者： Isha Chauhan , V.T. Beena , Lekshmy Srinivas , Sanish Sathyan , Moinak Banerjee
关键词:
摘要: Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects the oral mucous membrane as well skin. It cell-mediated autoimmune where T-cell-mediated immune response plays an important part in pathogenesis by causing damage to basal keratinocytes mucosa. Cytokine gene polymorphisms have unquestionable role orchestration of response, leading different functional scenarios, which turn influence outcome disease establishment and evolution. The purpose this study was understand these cytokine tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), IL-6 genes with OLP 101 individuals Malayalam-speaking ethnicity from South India (Kerala). We further investigated patients suffering other comorbid factors. Genotyping carried out polymerase chain reaction–restriction fragment length polymorphism. results...
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